Here are a few suggestions for your next trip from Siracusa

In 2 hours, you can reach Catania.

In 3 hours, you can reach Messina.

In 4 hours, you can reach Reggio Calabria.

In 5 hours, you can reach Palermo.

In 8 hours, you can reach Salerno.

In 9 hours, you can reach Rome, Naples.

In 10+ hours, you can reach Milan, Turin, Genoa, Bologna, Florence, Verona, Padova, Brescia, Taranto, Parma...