Düsseldorf
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Here are a few suggestions for your next trip from Karlovy Vary

In 4 hours, you can reach Praga.

In 5 hours, you can reach Múnich.

In 6 hours, you can reach Berlín, Linz.

In 7 hours, you can reach Viena, Brno, Ostrava.

In 8 hours, you can reach Bratislava, Hamburgo.

In 9 hours, you can reach Bruselas, Zúrich, Schaan, Basilea.

In 10+ hours, you can reach Roma, París, Bucarest, Budapest, Varsovia, Estocolmo, Copenhague, Ámsterdam, Zagreb, Liubliana...